Regulation of cellular functions by extracellular matrix.
نویسندگان
چکیده
منابع مشابه
Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions.
Suspension-induced terminal differentiation of human epidermal keratinocytes can be inhibited by fibronectin through binding to the alpha 5 beta 1 integrin. We have investigated the effect of fibronectin on expression of integrins and proteins of the actin cytoskeleton and have explored the nature of the differentiation stimulus by testing different combinations of anti-integrin monoclonal anti...
متن کاملRegulation of Schwann cell function by the extracellular matrix.
Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreadin...
متن کاملMulti-faceted regulation of cell differentiation by extracellular matrix.
Extracellular matrix (ECM) is an intricate network composed of an array of macromolecules, the importance of which is becoming increasingly apparent. The ECM is an integral part of the machinery that regulates cell function; its role in cell differentiation and tissue-specific gene expression, although essential, is not yet understood. It can act as a positive as well as a negative regulator of...
متن کاملRegulation of glucose-6-phosphatase by the extracellular matrix.
Glucose-6-phosphatase (EC 3.1.3.9) catalyses the terminal step of both gluconeogenesis and glycogenolysis. The enzyme comprises a multicomponent system found in the endoplasmic reticulum (E.R.) with the active site of the catalytic subunit directed towards the lumen of the E.R. [ 11. While there is much known about the hormonal regulation of the enzyme, there is a paucity of information on addi...
متن کاملRegulation of neurogenesis by extracellular matrix and integrins.
Deciphering the factors that regulate human neural stem cells will greatly aid in their use as models of development and as therapeutic agents. The complex interactions of cells with extracellular matrix (ECM) proteins probably contribute to proper central nervous system development mediating processes which regulate proliferation and differentiation of neural stem/rogenitor cells. Many of thes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1992
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v210s83